(3S)-3-hydroxy-3-methylglutaryl-CoA is a 3-hydroxy-3-methylglutaryl-CoA where the 3-hydroxy-3-methylglutaryl component has (S)-configuration. It has a role as a human metabolite and a mouse metabolite. It is a 3-hydroxy-3-methylglutaryl-CoA and a 3-hydroxy fatty acyl-CoA. It is a conjugate acid of a (3S)-3-hydroxy-3-methylglutaryl-CoA(5-).;HMG-CoA is a natural product found in Schizosaccharomyces pombe and Homo sapiens with data available.;3-Hydroxy-3-Methylglutaryl-Coenzyme A is an intermediate for the synthesis of mevalonic acid, ketone bodies and cholesterol and a metabolic product for leucine; it can be formed de novo from acetyl coenzyme A (CoA) and acetoacetyl CoA by HMG-CoA (3-Hydroxy-3-Methylglutaryl-Coenzyme A) synthase.;(S)-3-hydroxy-3-methylglutaryl-CoA is a metabolite found in or produced by Saccharomyces cerevisiae.