凯库乐欢迎您! 17558870519
工作时间【周一至周五 9点-17点】 English
您当前的位置:
Acetyl-CoA (Synonyms:乙酰基辅酶A;Acetyl coenzyme A)
目录号 : FMC0001 纯度 : BR/95%以上 品牌 : CHEMSOON Cas No. : 72-89-9 PubChem Id : 444493
Acetyl-CoA is an acyl-CoA having acetyl as its S-acetyl component. It has a role as an effector, a coenzyme, an acyl donor and a fundamental metabolite. It is functionally related to an acetic acid and a coenzyme A. It is a conjugate acid of an acetyl-CoA(4-).;Acetyl-CoA is a metabolite found in or produced by Escherichia coli (strain K12, MG1655).;Acetyl coenzyme A is a natural product found in Streptomyces clavuligerus, Schizosaccharomyces pombe, and other organisms with data available.;Acetyl Coenzyme A is the condensation product of coenzyme A and acetic acid which participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. In addition, Acetyl Coenzyme A acts as a biological acetylating agent.;Acetyl-CoA is a metabolite found in or produced by Saccharomyces cerevisiae.;Acetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent.
Acetyl-CoA
Cas No. : 72-89-9
规格编号 纯度 包装 库存 价格 拼团价
FMC0001-2mg BR/95%以上 2mg
面议
FMC0001-5mg BR/95%以上 5mg
面议
产品名称: Acetyl-CoA
其他名称: 乙酰基辅酶A;Acetyl coenzyme A
CAS:72-89-9
结构信息
分子式 C23H35N7O17P3S-3.3[H2O].3[LI+] 分子量 881.42
IUPAC Name  S-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] 3-hydroxy-2-methylbutanethioate
InChIKey  PEKYNTFSOBAABV-UHFFFAOYSA-N
InChI  InChI=1S/C26H44N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-15,18-20,24,34,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)
SMILES  CC(C(C)O)C(=O)SCCNC(=O)CCNC(=O)C(C(C)(C)COP(=O)(O)OP(=O)(O)OCC1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)O)OP(=O)(O)O)O
相关文献

1.De novo biosynthesis of alpha-zingiberene from glucose in Escherichia coli. Zhang, Suping et al. Biochemical Engineering Journal, 176, 108188; 2021

2.Engineering potassium activation into biosynthetic thiolase. Marshall, Andrew C. and Bruning, John B.. Biochemical Journal, 478(15), 3047-3062; 2021

3.Identification of an α-Oxoamine Synthase and a One-Pot Two-Step Enzymatic Synthesis of α-Amino Ketones. Zhou, Ting et al. Organic Letters, 23(1), 37-41; 2021

4.Engineered ethanol-driven biosynthetic system for improving production of acetyl-CoA derived drugs in Crabtree-negative yeast. Liu, Yiqi et al. Metabolic Engineering, 54, 275-284; 2019

5.Metabolic engineering of Clostridium acetobutylicum for the production of butyl butyrate. Noh, Hyeon Ji et al. Applied Microbiology and Biotechnology, 102(19), 8319-8327; 2018

6.Biocatalytic Total Synthesis of Ikarugamycin. Greunke, Christian et al. Angewandte Chemie, International Edition, 56(15), 4351-4355; 2017

7.Chemoenzymatic Synthesis of Acyl Coenzyme A Substrates Enables in Situ Labeling of Small Molecules and Proteins. Agarwal, Vinayak et al. Organic Letters, 17(18), 4452-4455; 2015

8.Synthesis of coenzyme A thioesters using methyl acyl phosphates in an aqueous medium. Pal, Mohan and Bearne, Stephen L.. Organic & Biomolecular Chemistry, 12(48), 9760-9763; 2014

9.LsrF, a coenzyme A-dependent thiolase, catalyzes the terminal step in processing the quorum sensing signal autoinducer-2. Marques, Joao C. et al. Proceedings of the National Academy of Sciences of the United States of America, 111(39), 14235-14240; 2014

10.Extending Carbon Chain Length of 1-Butanol Pathway for 1-Hexanol Synthesis from Glucose by Engineered Escherichia coli. Dekishima, Yasumasa et al. Journal of the American Chemical Society, 133(30), 11399-11401; 2011

11.Substrate Specificity of 2-Hydroxyglutaryl-CoA Dehydratase from Clostridium symbiosum: Toward a Bio-Based Production of Adipic Acid. Parthasarathy, Anutthaman et al. Biochemistry, 50(17), 3540-3550; 2011

12.On the thermodynamic equilibrium between (R)-2-hydroxyacyl-CoA and 2-enoyl-CoA. Parthasarathy, Anutthaman et al. FEBS Journal, 277(7), 1738-1746; 2010

13.Point Mutations (Q19P and N23K) Increase the Operational Solubility of a 2α-O-Benzoyltransferase that Conveys Various Acyl Groups from CoA to a Taxane Acceptor. Nawarathne, Irosha N. and Walker, Kevin D.. Journal of Natural Products, 73(2), 151-159; 2010

14.An N-Aroyltransferase of the BAHD Superfamily Has Broad Aroyl CoA Specificity in Vitro with Analogues of N-Dearoylpaclitaxel. Nevarez, Danielle M. et al. Journal of the American Chemical Society, 131(16), 5994-6002; 2009

15.Thioester hydrolysis and C-C bond formation by carboxymethylproline synthase from the crotonase superfamily. Batchelar, Edward T. et al. Angewandte Chemie, International Edition, 47(48), 9322-9325; 2008

16.Bacillus cereus strain 10-L-2 produces two arylamine N-acetyltransferases that transform 4-phenylenediamine into 4-aminoacetanilide. Mulyono et al. Journal of Bioscience and Bioengineering, 103(2), 147-154; 2007

17.A simple and efficient method to prepare thio-esters in aqueous solutions. Coleman, Tricia M. et al. Tetrahedron Letters, 46(25), 4307-4310; 2005

18.6-Deoxyerythronolide B Analogue Production in Escherichia coli through Metabolic Pathway Engineering. Kennedy, Jonathan et al. Biochemistry, 42(48), 14342-14348; 2003